A new study suggests that doxycycline can delay time to first episode of malaria. The study was published in the
Malariain the December issue ofThe Lancet. The results were published in
In the study, a group of 200 patients withPlasmodium falciparummalaria who received either a single dose of 200 mg of doxycycline daily for seven days or a combination of two single dose treatments, had a median of 7.8 days of malaria compared to 3.1 days in the group given either a single dose of 100 mg or 200 mg of doxycycline.
This was compared to the 7.8-day median of 4.7 days in the group given either a single dose of 100 mg or 200 mg of doxycycline.
The researchers found that while the malaria risk is lower in patients with a baseline risk of malaria, the risk is elevated in patients who are already at higher risk of malaria. Specifically, a study from the Centers for Disease Control and Prevention found a 3.2-fold risk of malaria in patients with a baseline risk of at least 4.0% compared to patients with a baseline risk of at least 5%.
In the group given either a single dose of 100 mg or 200 mg of doxycycline, the authors found a median of 2.6 days of malaria (range: 1.3-3.3 days), a median of 7.8 days of malaria compared to 3.1 days in the group given either a single dose of 100 mg or 200 mg of doxycycline. This was compared to a median of 2.6 days in the group given either a single dose of 100 mg or 200 mg of doxycycline.
In contrast, a study from the same group found that patients with a baseline risk of malaria at least 5.0% were twice as likely to develop malaria as those at least 5.0% had a baseline risk of at least 1.5%.
The researchers also found that patients who are already at high risk of malaria in a study of 5.0% or more, who are already at risk of malaria in a study of 4.0% or more, and who are already at risk of malaria in a study of 2.0% or more are at increased risk of malaria compared to the other 5.0% or more group of patients.
The researchers also found that patients who are already at high risk of malaria in a study of 3.2% or more, who are already at high risk of malaria in a study of 2.2% or more, and who are already at risk of malaria in a study of 2.2% or more are at increased risk of malaria compared to patients who are already at high risk of malaria in a study of 3.2% or more.
“Our findings suggest that patients with a baseline risk of malaria may already be at a greater risk of malaria compared to other groups of patients,” Dr. Thomas C. Hlatky, of the CDC/CDC, said in a statement. “Therefore, it is important to emphasize that patients with a baseline risk of malaria should be started early in the course of their illness and be monitored for signs and symptoms of malaria.”
For more information on Malaria and malaria, visit.
The Lancet is a monthly medical journal with a dedicated team of scientists, medical doctors, and travellers. Our content is grounded in scientific research and data-driven and not a substitute for the expertise and judgment of medical professionals. It is not designed for immediate access to the latest medical advancements or study modification, and for those who are in urgent need of support and/or guidance. This includes ongoing updates on topics such asRisk of MalariaandMalaria Prevention
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